Post-intervention Surgical Bypass Grafting
Post-intervention Stent Implantation
Dr. Motamed's research interests are in the areas of translational and basic cardiovascular mechanics. Using multidisciplinary research she tries to advance knowledge in biomechanics, fluid mechanics, solid mechanics, medical imaging and mathematical modelling. A major part of her work has been dedicated to development and validation of advanced multi-scale computational-mechanics and imaging-based algorithms for patient-specific modelling of cardiovascular system with the following objectives:
To develop long needed quantitative diagnostic, predictive and intervention-optimization tools for cardiovascular diseases to support personalized interventions and clinical decision making
To design, evaluate and optimize cardiovascular devices such as transcatheter heart valves and vascular stents
To uncover causes of cardiovascular pathologies through solving complex biomedical problems
To re-classify diseases and to establish guidelines for clinical interventions
To lead multidisciplinary collaborative efforts to translate engineering-based findings and developments into clinical practice
To develop monitoring tools for cardiovascular health to be integrated in future smart houses and smart vehicles
Due to the interdisciplinary nature of her research, Dr. Motamed extensively collaborates with engineers, clinical scientists, surgeons and cardiologists in Canada, USA and Europe.
Description of Ongoing Research
Despite advancements in surgical/interventional techniques, many cardiovascular patients do not respond favorably to treatments and their life expectancy remains reduced. Abnormal hemodynamics and biomechanics lay at the base of the initiation and progression of many cardiovascular diseases. Cardiovascular disease is the leading cause of death globally, taking more lives than all forms of cancer combined. It is expected to remain the first cause of death by 2030 in the world. Blood flow quantification can be greatly useful for accurate and early diagnosis of cardiovascular diseases. However the fluid-dynamics methods that can be used as calculating engines of the new diagnostic tools are yet to be developed. Furthermore, as most interventions intend to restore the healthy condition, the ability to predict hemodynamics and biomechanics resulting from a particular intervention has significant impacts on saving lives. Predictive methods are rare. They are extensions of diagnostic methods enabling prediction of effectiveness of interventions, allowing systematic testing for possible clinical solutions, and thus enabling personalization of interventions. The step beyond prediction is optimization of interventions to obtain the best possible outcome. Advancing computational mechanics offers a powerful means to augment clinical measurements and medical imaging to create non-invasive diagnostic, predictive and optimization tools. This is the aim behind a computational cardiovascular mechanics framework that Dr. Motamed's lab is developing. The framework was named Poiseuille to honour the 18th-century French physicist and physiologist Jean Leonard Marie Poiseuillewho provided a mathematical description for blood flow in vessels. Poiseuille is built for three folds of applications: diagnosis, prediction and intervention optimization. Poiseuille has one specific module for each of these applications and one common module that contain shared programs serving the three application modules. Currently Poiseuille is under active development. These developments present formidable mathematical and computational challenges: modeling must incorporate the motion of fluid and the motion of vessel wall, a large network of the blood vessels with complicated geometries, persistent pulse-driven changes in flow and pressure, and in some cases behavior of red blood cells. Poiseuille also provides the backbone for developing new monitoring tools for cardiovascular health to be integrated in future smart houses and smart vehicles.